Infliximab (Remicade)

Infliximab is a type of biologic (antibody based) medication called TNF inhibitors. These medications work by targeting tumor necrosis factor (TNF) which is a protein that causes inflammation. Infliximab and other TNF inhibitors are used to treat inflammatory conditions such as rheumatoid arthritis, psoriatic arthritis, juvenile idiopathic arthritis, inflammatory bowel disease (Crohn’s and ulcerative colitis), ankylosing spondylitis, and psoriasis amongst others.

Infliximab can be used alone or in combination with other medications such as prednisone, methotrexate, hydroxychloroquine, leflunomide or sulfasalazine.

How To Take It

Infliximab is most commonly given as an infusion into a vein, typically every 4–8 weeks. This can be done at healthcare facilities, like hospitals or infusion centers, and each dose may take a few hours. In some cases, infusions can be given at home depending on insurance coverage. Before the infusion, other medications such as steroids or Tylenol may be given to prevent reactions to infliximab.

Some patients feel better after 1 or 2 doses, but it may take 3–6 months to see the full benefit.

It is important to stay on track with your infusion schedule to make sure that this medication keeps working.

Side Effects

Infliximab can increase the risk of infection, including serious infections. Testing for tuberculosis and hepatitis is recommended before starting treatment with infliximab.

Infusion reactions such as fever, hives, rashes, and difficulty breathing can occur in less than 5% (5 in 100) patients receiving infliximab. Delayed reactions are rare but can occur several days after an infusion, symptoms can include fever, muscle pain, joint pain, and rashes.

Infliximab may increase the risk of certain types of skin cancer, so sun protection is recommended including wearing protective clothing, applying sunscreen, and avoiding sun exposure in the middle of the day.

In rare cases (less than 1% or fewer than 1 in 100 patients), TNF inhibitors, including infliximab, have been associated with new autoimmune conditions including multiple sclerosis, drug-induced lupus, and psoriasis.

Tell Your Rheumatology Provider

Before starting infliximab, talk to your rheumatologist if you are pregnant or are planning to become pregnant. Infliximab use has not been associated with fertility problems, miscarriages, or other pregnancy related complications such as preterm birth. Breastfeeding while on infliximab is considered safe for infants.

While on infliximab, contact your rheumatologist if you develop symptoms of an infection like fever or shaking chills or if you plan to undergo any surgery, because infliximab may need be held for some time before and after surgery. Patients should talk to their rheumatology provider before getting any vaccinations while on infliximab. Many vaccinations are safe, but live vaccines should be avoided.

Updated June 2026 by Elizabeth Graef, DO, and reviewed by the American College of Rheumatology Communications and Marketing Committee.

This information is provided for general education only. Individuals should consult a qualified health care provider for professional medical advice, diagnosis and treatment of a medical or health condition.