Abaloparatide (Tymlos)

Abaloparatide (Tymlos) is a medicine approved for treatment of osteoporosis in postmenopausal women and in men. Osteoporosis makes bones weak and easier to break. This medicine helps your body build new bone. It works similar to a natural hormone in your body, called parathyroid hormone that helps control bone strength. Abaloparatide is considered an anabolic treatment for osteoporosis because it builds bone. Studies show it greatly reduced the chance of breaking a bone in people with osteoporosis.

How To Take It

Abaloparatide is a daily injection given under the skin. It comes in a pen containing four weeks of medication and is injected under the skin of the stomach every day with a very small needle. The site of your daily injection should change every day to reduce skin irritation. You should inject the medicine at the same time every day. Once the pen is used, it can be kept at room temperature for the remaining doses or stored in the refrigerator.

To get the most benefit from use of abaloparatide, be sure to eat calcium-rich foods and/or take a calcium supplement. Total calcium intake from food and supplements should be at least 1,200 mg per day. Also take vitamin D as recommended by your provider.

Side Effects

Most people take this medication without serious problems. The most common side effect is redness or irritation where the medicine is injected. Less commonly, people can get high blood or urine calcium levels from taking the medicine. Within four hours of injecting the medicine, some people have low blood pressure or feel dizzy. If this happens, your provider might ask you to inject the medicine when sitting or lying down. [GU1.1]Use of abaloparatide is limited to two years for safety and efficacy reasons.

Tell Your Rheumatology Provider

Please contact your provider if you become pregnant or plan to get pregnant while taking abaloparatide, which should not be used during pregnancy. If you experience severe dizziness or fainting with injections, you should also contact your provider.

Updated January 2026 by Nina Couette, DO, and reviewed by the American College of Rheumatology Communications and Marketing Committee.

This information is provided for general education only. Individuals should consult a qualified health care provider for professional medical advice, diagnosis and treatment of a medical or health condition.