Anifrolumab-fnia (Saphnelo)

Anifrolumab is a medicine used as an add-on treatment for adult with moderate to severe systemic lupus erythematosus (SLE), a disease in which the immune system attacks the body causing inflammation and organ damage. Currently, anifrolumab is not approved for treating lupus affecting the kidneys (nephritis) or lupus affecting the central nervous system. Anifrolumab may be used in combination with other drugs, such as hydroxychloroquine and glucocorticoids (steroids). It works by blocking molecules that can trigger the immune system to attack normal cells and tissues.

How To Take It

Anifrolumab is given as an infusion. Infusions are administered through a needle that is inserted in a vein by a healthcare professional. The infusions last for about 30 minutes and must be repeated every four weeks. Anifrolumab has improved lupus affecting the skin and joints (arthritis). Anifrolumab does not require laboratory monitoring, but your rheumatology team may continue to follow your blood work.

Side Effects

Anifrolumab can cause side effects, but most are mild, such as sinus congestion, upper respiratory tract infection, or bronchitis (inflammation of the airways in the lungs). Rarely it can cause serious infections such as shingles. We do not know if anifrolumab is safe to use during pregnancy or breast feeding currently.

Tell Your Rheumatology Provider

If you develop symptoms of an infection, such as a fever, cough, burning with urination, or rash or if you think you are experiencing any side effects or allergic reactions.

Consult with the rheumatology provider if you have become pregnant, are planning pregnancy, or are breastfeeding. The risk in pregnancy and breastfeeding has not been determined. If you are planning to have surgery, the drug may need to be held before surgery. If you plan to get any live vaccinations, including the nasal spray flu vaccine, some types of shingles vaccine, and others such as the measles, mumps, rubella, and yellow fever vaccines please let your provider know before you take the live vaccine.

Updated April 2025 by Howard Yang, MD, and reviewed by the American College of Rheumatology Committee on Communications and Marketing.

This information is provided for general education only. Individuals should consult a qualified health care provider for professional medical advice, diagnosis, and treatment of a medical or health condition.