Voclosporin (Lupkynis)
The FDA approved voclosporin in 2021 to treat adult patients with active lupus nephritis (kidney inflammation due to lupus). Voclosporin is used in combination with other drugs, including (but not limited to) hydroxychloroquine (Plaquenil), glucocorticoids (steroids), and mycophenolate mofetil (CellCept). This medication decreases the immune system's strength. In clinical trials for lupus nephritis, those patients receiving voclosporin were twice as likely to respond favorably to treatment (reduced kidney inflammation) than those who did not receive voclosporin.
How To Take It
Voclosporin is a capsule that is taken twice a day (12 hours apart) on an empty stomach. Patients with lupus nephritis who have very low kidney function or very high blood pressure may not be able to start this drug. Blood tests are needed to monitor changes in kidney function and potassium levels. Also, if you start voclosporin, your provider will ask you to check your blood pressure every two weeks for the first month.
Patients taking vosclosporin should avoid eating grapefruit or drinking grapefruit juice as it can increase the levels of voclosporin in your blood.
Patients who develop low kidney function after taking voclosporin should follow up with their healthcare provider to adjust the dose.
Side Effects
Voclosporin may increase your risk of infection, increase blood pressure, increase potassium levels, and may also cause kidney dysfunction. Prolonged use of voclosporin may increase the risk of some cancers such as lymphoma and skin cancers. Regular lab monitoring and follow up with your rheumatologist is important in evaluating these potential side effects.
Tell Your Rheumatology Provider
Inform your rheumatologist if you start any new medications since voclosporin may interact with many other drugs. You should notify your rheumatology provider if you develop symptoms of an infection, such as a fever or cough, or if you think you have any side effects or allergic reactions. Notify your doctor if you have become pregnant, are planning pregnancy, or are breastfeeding. Be sure to talk with your rheumatology provider if you are planning to have surgery as the medication may need to be stopped before surgery to improve recovery and reduce risk of infection. The risk in pregnancy and breastfeeding has not been determined. Therefore, voclosporin should be avoided in pregnant and breastfeeding women.
Updated March 2025 by Diana Girnita MD, PhD, and reviewed by the American College of Rheumatology Committee on Communications and Marketing.
This information is provided for general education only. Individuals should consult a qualified health care provider for professional medical advice, diagnosis, and treatment of a medical or health condition.